Jack Albert Loeppky

Ph.D., is a Scientist in NMR and a Research Assistant in the Division of Cardiology at the VA Medical Center in Albuquerque. He has the following research interests in mammalian Respiratory and Environmental Physiology:

• normal and pathological pulmonary physiology and gas exchange
• effects of hypoxia and hypercapnia
• pulmonary blood flow determinations from respiratory gases
• changes in body gas stores in response to gravitational stress
• pulmonary ventilation/perfusion distributions and their influence on respiratory gas exchange
• fluid balance changes with simulated microgravity and high altitude
• pulmonary gas exchange at high altitude
• effects of acute mountain sickness on human brain magnetic resonance images

Education and Employment History

B.A.(Physical Ed., Physiology), University of Saskatchewan, Saskatoon, Canada, 1966
M.S.(Physical Ed., Physiology), University of New Mexico, Albuquerque, NM, 1969
Physiology and Biophysics, Colorado State University, Fort Collins, CO, 1970
Ph.D.(Biology), University of New Mexico, Albuquerque, NM

• 1963: Research Assistant, Biology, University of Saskatchewan, Saskatoon, Canada
• 1966-1967: Instructor, Physical Ed., University of Saskatchewan, Canada
• 1967: Research Assistant, Physiology and Pharmacology, University of Saskatchewan, Canada
• 1967-1968: Graduate and Teaching Assistant, Physical Ed. and Exercise Physiology, University of New Mexico, Albuquerque, NM
• 1968-1969: Technician, Physiology and Biomedical Engineering, Lovelace Medical Foundation, Albuquerque, NM
• 1969: Instructor, Physiology Laboratory, Colorado State University, Fort Collins, CO and Research Assistant, Institute of Arctic Biology, Alaska
• 1970-1975: Research Associate, Physiology, Lovelace Medical Foundation, Albuquerque, NM
• 1975: Technologist-in-Charge, Respiratory Physiology Laboratory, Welling­ton Hospital, Wellington, New Zealand
• 1975-1990: Associate Scientist, Research Division, Lovelace Medical Foundation, Albuquerque, NM
• 1979-1983: Technical Director, Clinical Sleep Laboratory, Lovelace Medical Center, Albuquerque, NM
• 1981-1983: Chairman, Cardiopulmonary Physiology, Research Division, Lovelace Medical Foundation, Albuquerque, NM
• 1982-present: Adjunct Assistant Professor of Health, Physical Education and Recreation (Exercise Science), University of New Mexico, Albuquerque, NM
• 1983-1984: Visiting Scientist, Max-Planck-Institute for Experimental Medicine, Göttingen, Germany.
• 1990-2000: Scientist, Lovelace Respiratory Research Institute (LRRI), formerly The Lovelace Institutes (TLI), formerly Lovelace Medical Foundation, Albuquerque, NM

Other Teaching Experience:

• Course lectures: University of Albuquerque and University of New Mexico in Physiology, Biology and Exercise Science
• Graduate course in Respiratory Physiology, University of New Mexico, 1982
• Nine Graduate Student committees, University of New Mexico
• Research supervision of 11 summer students

Awards and Honors:

• American Physiological Society Travel Grant, 1981
• American Heart Association (New Mexico Affiliate) Grant-in-Aid for "Cerebrovascular response to CO2 and hypoxia in sleep apnea," July 1, 1982 to June 30, 1984
• Max-Planck-Institute (Göttingen, Germany) Research Fellowship, 1983-1984
• National Science Foundation Grant for Cooperative Research, 1984
• American Heart Association (New Mexico Affiliate) Grant-in-Aid for "Combined effects of hypoxia and body fluid shifts on cardiopulmonary function and lung water content", July 1, 1988 to June 30, 1989
• National Aeronautics and Space Administration (NASA) Grant (NAG 9-375/Basic) for "Interaction between hypoxia and simulated microgravity", May 1, 1989 to April 30, 1992; Renewal Grant: May 1, 1992 to April 30, 1995
• Clinical Research Center, University of New Mexico: Financial support for "Effects of barometric pressure and hypoxia on fluid balance and altitude illness," 1993
• US Army, Research contract for “Pathophysiology of acute mountain sickness in women”, October1, 1996 to February 1, 2000
• Reviewer for:
      Journal of Applied Physiology
      Aviation, Space and Environmental Medicine
      International Journal of Biometeorology
      Quarterly Journal of Experimental Physiology
      Journal of Clinical Pharmacology
      Medicine and Science in Sports and Exercise
      European Respiratory Journal

Affiliations:

• Associate Member, American Physiological Society, August 1974
• Regular Member, American Physiological Society, April 1979
• Adjunct Assistant Professor of Health, Physical Education and Recreation (Exercise Science), University of New Mexico, January 1982 to present
• Charter Member, International Society for Gravitational Physiology, January 1993

Selected Publications:

• Loeppky J.A., Luft U.C. Fluctuations in O₂ stores and gas exchange with passive changes in posture. Journal of Applied Physiology. 39: 47-53, 1975.
• Loeppky J.A., Myhre L.G., Venters M.D., Luft U.C. Total body water and lean body mass estimated by ethanol dilution. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 42: 803-808, 1977.
• Luft U.C., Loeppky J.A., Mostyn E.M. Mean alveolar gases and alveolar-arterial gradients in pulmonary patients. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 46: 534-540, 1979.
• Loeppky J.A., Riedesel M.L. (Editors). Oxygen Transport to Human Tissues. Proceedings of a symposium in honor of Dr. U.C. Luft, held June 25-27, 1981 in Albuquerque, NM. New York: Elsevier/North-Holland, 405 pages, 1982.
• Loeppky J.A., Luft U.C., Fletcher E.R. Quantitative description of whole blood CO₂ dissociation curve and Haldane effect. Respiration Physiology. 51:167-181, 1983.
• Loeppky J.A., Hoekenga D.E., Greene E.R., Luft U.C. Comparison of noninvasive pulsed Doppler and Fick measurements of stroke volume in cardiac patients. American Heart Journal. 107: 339-346, 1984.
• Loeppky J.A., Scotto P., Rieke H., Meyer M., Piper J. Arterial-alveolar CO₂ equilibration in exercising dogs during prolonged rebreathing. Journal of Applied Physiology. 58: 1654-1658, 1985.
• Loeppky J.A., Scotto P., Piiper J. Transient PO₂ and PCO₂ differences between end-tidal gas and arterial blood during rebreathing in awake dogs. Respiration Physiology. 60: 135-144, 1985.
• Loeppky J.A., Miranda F.G., Eldridge M.W. Abnormal cerebrovascular re­sponses to CO₂ in sleep apnea patients. Sleep. 7:97-109, 1984 and Pulmonary Disease Reviews, Vol. 6, Edited by Bone R.C., New York, John Wiley and Sons, 614-622, 1986.
• Loeppky J.A., Fletcher E.R., Myhre L.G., Luft U.C. Validation and application of single breath cardiac output determinations in man. Aviation, Space and Environmental Medicine. 57: 759-768, 1986.
• Loeppky J.A., Voyles W.F., Eldridge M.W, Sikes C.W. Sleep apnea and autonomic cerebro­vascular dysfunction. Sleep. 10: 25-34, 1987.
• Scotto P., Loeppky J.A., Piiper J., Farhi L.E. Acid-base status immediately following rapid changes of alveolar gas composition in awake dogs. Respiration Physiology. 68: 251-258, 1987.
• Loeppky J.A., Hirshfield D.W., Eldridge M.W. The effects of head-down tilt on carotid blood flow and pulmonary gas exchange. Aviation, Space and Environmental Medicine. 58: 637-644, 1987.
• Loeppky J.A., Caprihan A., Luft U.C. V_A/Q inequality during clinical hypoxemia and its alterations. In: Man in Stressful Environments: Diving, Hyper-and Hypobaric Physiology, Edited by Shiraki K, Yousef M.K. Springfield, IL: CC Thomas, 199-232, 1987.
• Chick T.W., Scotto P., Icenogle M.V, Sikes C.W., Doyle M.P., Riedel CE, Wood SC, Loeppky J.A. Effects of pentoxifylline on pulmonary hemodynamics during acute hypoxia in anesthetized dogs. American Review of Respiratory Disease. 137: 1099-1103, 1988.
• Loeppky J.A., Luft U.C. Work capacity, exercise responses and body composition of professional pilots in relation to age. Aviation, Space and Environmental Medicine. 60: 1077-1084, 1989.
• Loeppky J.A., Scotto P., Chick T.W., Luft U.C. Effects of acute hypoxia on cardiopulmonary responses to head-down tilt. Aviation, Space and Environmental Medicine. 61: 785-794, 1990.
• Loeppky J.A., Scotto P., Riedel C., Avasthi P., Koshukoshy V., Chick T.W. Cardiopulmonary responses to acute hypoxia, head-down tilt, and water loading in anesthetized dogs. Aviation, Space and Environmental Medicine. 62: 1137-1146, 1991.
• Loeppky J.A., Scotto P., Riedel C.E., Roach R., Chick T.W. Effects of acid-base status on acute hypoxia pulmonary vasoconstriction and gas exchange. Journal of Applied Physiology. 72: 1789-1797, 1992.
• Loeppky J.A., Fletcher E.R., Roach R.C., Luft U.C. Relationship between whole blood base excess and CO₂ content in vivo. Respiration Physiology. 94: 109-120, 1993.
• Loeppky J.A., Roach R.C., Selland M.A., Scotto P., Luft F.C., Luft U.C. Body fluid alterations during head-down bedrest at moderate altitude. Aviation, Space and Environmental Medicine. 64: 265-274, 1993.
• Loeppky J.A., Roach R.C., Selland M.A., Scotto P., Greene E.R., Luft U.C. Effects of prolonged head-down bedrest on physiological responses to moderate hypoxia. Aviation, Space and Environmental Medicine. 64: 275-286, 1993.
• Melo M.F.V, Loeppky J.A., Caprihan A., Luft U.C. Alveolar ventilation to perfusion heterogeneity and diffusion impairment in a mathematical model of gas exchange. Computers and Biomedical Research. 26: 103-120, 1993.
• Whitson P.A., Cintron N.M., Pietrzyk R.A., Scotto P., Loeppky J.A. Acute effects of head-down tilt and hypoxia on modulators of fluid homeostasis. Journal of Clinical Pharmacology. 34: 427-433, 1994.
• Roach R.C., Loeppky J.A., Icenogle M.V. Acute mountain sickness: increased severity during simulated altitude compared with normobaric hypoxia. Journal of Applied Physiology. 81: 1908-1910, 1996.
• Loeppky J.A., Scotto P, Roach R.C. Acute ventilatory response to simulated altitude, normobaric hypoxia and hypobaria. Aviation, Space and Environmental Medicine. 67: 1019-1022, 1996.
• Loeppky J.A., Icenogle M., Scotto P., Robergs R., Hinghofer-Szalkay H., Roach R.C. Ventilation during simulated altitude, normobaric hypoxia and normoxic hypobaria. Respiration Physiology. 107: 231-239, 1997.
• Loeppky J.A. The effects of low levels of CO₂ on ventilation during rest and exercise. Aviation, Space and Environmental Medicine. 69: 368-373, 1998.
• Caprihan A., Sanders J.A., Cheng H.A., Loeppky J.A. Effect of head-down tilt on brain water distribution. European Journal of Applied Physiology and Occupational Medicine. 79: 367-373, 1999.
• Loeppky J.A., Kuethe D.O., Altobelli S.A., Scotto P., Piiper J. Effects of gas density on experimentally obstructed ventilation during acute hypoxia. Respiration Physiology. 117: 151-160, 1999.
• Roach R.C., Maes D., Sandoval D., Robergs R.A., Icenogle M., Hinghofer-Szalkay H., Lium D., Loeppky J.A. Exercise exacerbates acute mountain sickness at simulated high altitude. Journal of Applied Physiology. 88: 581-585, 2000.